The State of Oregon has activated a multi-agency response plan following the confirmation of highly pathogenic H5 avian influenza in domestic birds in Douglas County. The Oregon Department of Agriculture is the lead state agency responding to the incident, working closely with the Oregon Department of Fish and Wildlife, and Oregon Health Authority. There is no immediate public health concern due to the avian influenza virus detected in Oregon. H5N8 virus has been found in other parts of the world and has not caused any human infection to date. Avian influenza does not affect poultry meat or egg products, which remain safe to eat. As always, both wild and domestic poultry should be properly cooked. The H5N8 avian influenza virus was confirmed by USDA in guinea fowl and chickens from a small backyard poultry flock in Winston, Oregon. The flock of approximately 100 birds has access to the outdoors. A pond and a marsh on the premises are frequented by migratory birds. The virus has not been found in commercial poultry anywhere in the US. Surveillance for avian influenza is ongoing in commercial poultry operations, live bird markets, and in migratory wild bird populations.